The MCG Pediatric Podcast

Trisomy 13 & 18 Cardiac Surgery with Dr. James St. Louis

July 1, 2021

Trisomy 13 & 18 Cardiac Surgery with Dr. James St. Louis


  • James St. Louis, MD
  • Zachary Hodges, MD

Peer review by Dr. Pushpa Shivaram and the MCG Pediatric Podcast Committee

About our Guest:

Dr. James St. Louis is the J. Harold Harrison, MD Distinguished Chair in Pediatrics, Surgery and Cardiothroacic Surgery at the Medical College of Georgia. He is the Chief of Pediatric Cardiothoracic and Congenital Cardiac Surgery at the Children’s Hospital of Georgia. 

Learning Objectives:

After listening to this podcast, learners should be able to:

  1. Recognize the prevalence of congenital heart disease in children with Trisomy 13 & 18.
  2. Recall the limited access to cardiac surgery historically offered to children with Trisomy 13 & 18.
  3. Describe the general recent trends in pediatric cardiothoracic surgery for children with Trisomy 13 & 18, specifically increased access to surgical repair of relative low complexity lesions.
  4. Describe which cardiac abnormalities are increasingly being offered surgical repair by some centers.
  5. Recognize key factors or comorbidities that might guide the decision to offer or withhold corrective surgery for children with Trisomy 13 & 18.
  6. Generally, recognize which complex and multi-stage procedures are currently not being offered to children with Trisomy 13 & 18.
  7. Recognize the current variability of surgical options being offered between different centers.
  8. Describe what types of cardiac surgery are being offered to children with Trisomy 13 & 18 here at the Medical College of Georgia.

Thank you for listening to this episode from the Department of Pediatrics at the Medical College of Georgia. If you have any comments, suggestions, or feedback- you can email us at

Remember that all content during this episode is intended for informational and educational purposes only. It should not be used as medical advice to diagnose or treat any particular patient. Clinical vignette cases presented are based on hypothetical patient scenarios. We look forward to speaking to you on our next episode of the MCG Pediatric Podcast.  

Free CME Credit:


  1. McCaffrey MJ. Trisomy 13 and 18: Selecting the road previously not taken. Am J Med Genet C Semin Med Genet. 2016;172(3):251-256. doi:10.1002/ajmg.c.31512 
  2. Bajinting A, Munoz-Abraham AS, Osei H, Kirby AJ, Greenspon J, Villalona GA. To operate or not to operate? Assessing NSQIP surgical outcomes in trisomy 18 patients [published online ahead of print, 2020 Jun 5]. J Pediatr Surg. 2020;S0022-3468(20)30369-9. doi:10.1016/j.jpedsurg.2020.05.037 
  3. Neubauer K, Boss RD. Ethical considerations for cardiac surgical interventions in children with trisomy 13 and trisomy 18. Am J Med Genet C Semin Med Genet. 2020;184(1):187-191. doi:10.1002/ajmg.c.31767 
  4. Nelson KE, Rosella LC, Mahant S, Guttmann A. Survival and Surgical Interventions for Children With Trisomy 13 and 18 [published correction appears in JAMA. 2017 May 2;317(17 ):1803]. JAMA. 2016;316(4):420-428. doi:10.1001/jama.2016.9819 

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